Belangrijke publicaties over herhaalde miskramen
Covid vaccinaties leiden niet tot meer miskramen, Februari 2023
T4 life studie, mei 2022
Bij vrouwen met herhaalde miskramen in de voorgeschiedenis en antistoffen tegen de schildklier, geeft het toedienen van schildklierhormoon geen betere uitkomsten. Bij vrouwen met herhaalde miskramen (2 of meer) komt het vaker voor dat er antistoffen tegen de schildklier worden gevonden. Deze schildklier auto-immuniteit is aanwezig als er TPO-antistoffen (antistoffen tegen schildklier receptor) aanwezig zijn, de schildklier zelf werkt normaal. Er is onderzocht of toediening van levothyroxine, (medicijn dat schildklierhormoon bevat), de kans op een miskraam kan verkleinen. In totaal hebben 187 vrouwen deelgenomen aan dit onderzoek. 50% van de vrouwen heeft levothyroxine gebruikt en 50% heeft een placebo gekregen.
Uit de T4 life studie blijkt dat de kans op een levend geboren kind NIET toeneemt bij het gebruik van Levothyroxine.
Publicaties van onze onderzoeksgroep
du Fossé NA, van der Hoorn MP, van Lith JMM, le Cessie S, Lashley EELO. Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2020 Sep 1;26(5):650-669. doi: 10.1093/humupd/dmaa010. PMID: 32358607; PMCID: PMC7456349.
Youssef A, Vermeulen N, Lashley EELO, Goddijn M, van der Hoorn MLP. Comparison and appraisal of (inter)national recurrent pregnancy loss guidelines. Reprod Biomed Online. 2019 Sep;39(3):497-503. doi: 10.1016/j.rbmo.2019.04.008. Epub 2019 Apr 25. PMID: 31182358.
Béquet YLBN, Lashley EELO, Goddijn M, van der Hoorn MP. The role of uterine natural killer cells in recurrent pregnancy loss and possible treatment options. Fertil Steril. 2023 Nov;120(5):945-947. doi: 10.1016/j.fertnstert.2023.08.949. Epub 2023 Aug 26. PMID: 37640099.
Tian X, Goemaere NNT, van der Meeren L, Yang J, Kapsenberg JM, Lashley LEELO, Eikmans M, van der Hoorn MP. Inflammatory placental lesions are specifically observed in healthy oocyte donation pregnancies with extreme fetal-maternal incompatibility. Placenta. 2023 Nov;143:100-109. doi: 10.1016/j.placenta.2023.10.005. Epub 2023 Oct 10. PMID: 37866320.
van der Hoorn ML, Lashley EE, Bianchi DW, Claas FH, Schonkeren CM, Scherjon SA. Clinical and immunologic aspects of egg donation pregnancies: a systematic review. Hum Reprod Update. 2010 Nov-Dec;16(6):704-12. doi: 10.1093/humupd/dmq017. Epub 2010 Jun 12. PMID: 20543201.
Scherjon S, Lashley L, van der Hoorn ML, Claas F. Fetus specific T cell modulation during fertilization, implantation and pregnancy. Placenta. 2011 Oct;32 Suppl 4:S291-7. doi: 10.1016/j.placenta.2011.03.014. Epub 2011 May 17. PMID: 21592567.
Youssef A, Lashley EELO, Vermeulen N, van der Hoorn MLP. Identifying discrepancies between clinical practice and evidence-based guideline in recurrent pregnancy loss care, a tool for clinical guideline implementation. BMC Pregnancy Childbirth. 2023 Jul 28;23(1):544. doi: 10.1186/s12884-023-05869-y. PMID: 37507697; PMCID: PMC10386208.
van der Hoorn ML, van Bentem K, Lashley E. Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians. Reprod Sci. 2022 Dec;29(12):3311-3320. doi: 10.1007/s43032-021-00821-x. Epub 2022 Jan 3. PMID: 34981463.
van der Hoorn MP, Lashley EELO. Effect van progesteron bij zwangerschapscomplicaties [Effectiveness of progesterone in pregnancy complications]. Ned Tijdschr Geneeskd. 2019 Oct 24;163:D4395. Dutch. PMID: 31682091.
van ’t Hof LJ, Schotvanger N, Haasnoot GW, van der Keur C, Roelen DL, Lashley LEELO, Claas FHJ, Eikmans M, van der Hoorn MP. Maternal-Fetal HLA Compatibility in Uncomplicated and Preeclamptic Naturally Conceived Pregnancies. Front Immunol. 2021 May 13;12:673131. doi: 10.3389/fimmu.2021.673131. PMID: 34054856; PMCID: PMC8155594.
van Bentem K, Bos M, van der Keur C, Kapsenberg H, Lashley E, Eikmans M, van der Hoorn ML. Different immunoregulatory components at the decidua basalis of oocyte donation pregnancies. Hum Immunol. 2022 Apr;83(4):319-327. doi: 10.1016/j.humimm.2021.10.008. Epub 2021 Nov 14. PMID: 34785097.
Keller CC, Eikmans M, van der Hoorn MP, Lashley LEELO. Recurrent miscarriages and the association with regulatory T cells; A systematic review. J Reprod Immunol. 2020 Jun;139:103105. doi: 10.1016/j.jri.2020.103105. Epub 2020 Mar 5. PMID: 32199194.
van der Hoorn ML, Lashley L. Value of Ethnicity or Race in More Accurate Prediction of Future Outcome in Couples with Recurrent Miscarriages. Reprod Sci. 2022 Jul;29(7):2079-2080. doi: 10.1007/s43032-022-00942-x. Epub 2022 Apr 28. PMID: 35484465; PMCID: PMC9287212.
du Fossé NA, van der Hoorn MP, de Koning R, Mulders AGMGJ, van Lith JMM, le Cessie S, Lashley EELO. Toward more accurate prediction of future pregnancy outcome in couples with unexplained recurrent pregnancy loss: taking both partners into account. Fertil Steril. 2022 Jan;117(1):144-152. doi: 10.1016/j.fertnstert.2021.08.037. Epub 2021 Dec 1. PMID: 34863518.
du Fossé NA, Lashley EELO, Anholts JDH, van Beelen E, le Cessie S, van Lith JMM, Eikmans M, van der Hoorn MLP. Impaired immunomodulatory effects of seminal plasma may play a role in unexplained recurrent pregnancy loss: Results of an in vitro study. J Reprod Immunol. 2022 Jun;151:103500. doi: 10.1016/j.jri.2022.103500. Epub 2022 Feb 19. PMID: 35278895.
van Bentem K, van der Hoorn ML, van Lith J, le Cessie S, Lashley E. Development of hypertensive complications in oocyte donation pregnancy: protocol for a systematic review and individual participant data meta-analysis (DONOR IPD). BMJ Open. 2022 Jul 18;12(7):e059594. doi: 10.1136/bmjopen-2021-059594. PMID: 35851011; PMCID: PMC9297201.
du Fossé N, van der Hoorn ML, Eikmans M, Heidt S, le Cessie S, Mulders A, van Lith J, Lashley E. Evaluating the role of paternal factors in aetiology and prognosis of recurrent pregnancy loss: study protocol for a hospital-based multicentre case-control study and cohort study (REMI III project). BMJ Open. 2019 Nov 14;9(11):e033095. doi: 10.1136/bmjopen-2019-033095. PMID: 31727666; PMCID: PMC6887057.
du Fossé NA, Lashley EELO, Treurniet TT, van Lith JMM, le Cessie S, Boosman H, van der Hoorn MLP. Exploring gender differences among couples with unexplained recurrent pregnancy loss regarding preferences for supportive care. BMC Pregnancy Childbirth. 2021 Nov 30;21(1):796. doi: 10.1186/s12884-021-04277-4. PMID: 34847864; PMCID: PMC8630871.
Youssef A, van der Hoorn MLP, Dongen M, Visser J, Bloemenkamp K, van Lith J, van Geloven N, Lashley EELO. External validation of a frequently used prediction model for ongoing pregnancy in couples with unexplained recurrent pregnancy loss. Hum Reprod. 2022 Mar 1;37(3):393-399. doi: 10.1093/humrep/deab264. PMID: 34875054.
van Bentem K, Lashley E, Bos M, Eikmans M, Heidt S, Claas F, le Cessie S, van der Hoorn ML. Relating the number of human leucocytes antigen mismatches to pregnancy complications in oocyte donation pregnancies: study protocol for a prospective multicentre cohort study (DONOR study). BMJ Open. 2019 Jul 24;9(7):e027469. doi: 10.1136/bmjopen-2018-027469. PMID: 31345965; PMCID: PMC6661658.
Youssef A, van der Hoorn ML, van Eekelen R, van Geloven N, van Wely M, Smits MAJ, Mulders A, van Lith JM, Goddijn M, Lashley E. Development of the OPAL prediction model for prediction of live birth in couples with recurrent pregnancy loss: protocol for a prospective and retrospective cohort study in the Netherlands. BMJ Open. 2022 Sep 23;12(9):e062402. doi: 10.1136/bmjopen-2022-062402. PMID: 36153018; PMCID: PMC9511582.
du Fossé NA, Lashley EELO, van Beelen E, Meuleman T, le Cessie S, van Lith JMM, Eikmans M, van der Hoorn MLP. Identification of distinct seminal plasma cytokine profiles associated with male age and lifestyle characteristics in unexplained recurrent pregnancy loss. J Reprod Immunol. 2021 Sep;147:103349. doi: 10.1016/j.jri.2021.103349. Epub 2021 Jul 8. PMID: 34246867.
Lashley LE, van der Hoorn ML, van der Mast BJ, Tilburgs T, van der Lee N, van der Keur C, van Beelen E, Roelen DL, Claas FH, Scherjon SA. Changes in cytokine production and composition of peripheral blood leukocytes during pregnancy are not associated with a difference in the proliferative immune response to the fetus. Hum Immunol. 2011 Oct;72(10):805-11. doi: 10.1016/j.humimm.2011.05.027. Epub 2011 Jun 12. PMID: 21708204.
Lashley LE, van der Hoorn ML, Haasnoot GW, Roelen DL, Claas FH. Uncomplicated oocyte donation pregnancies are associated with a higher incidence of human leukocyte antigen alloantibodies. Hum Immunol. 2014 Jun;75(6):555-60. doi: 10.1016/j.humimm.2014.02.016. Epub 2014 Feb 12. PMID: 24530746.
van Bentem K, Bos M, van der Keur C, Brand-Schaaf SH, Haasnoot GW, Roelen DL, Eikmans M, Heidt S, Claas FHJ, Lashley EELO, van der Hoorn MLP. The development of preeclampsia in oocyte donation pregnancies is related to the number of fetal-maternal HLA class II mismatches. J Reprod Immunol. 2020 Feb;137:103074. doi: 10.1016/j.jri.2019.103074. Epub 2019 Dec 5. PMID: 31864034.
van Bentem K, Lashley L, van der Hoorn ML. Significance of specialised preconception counselling in oocyte donation pregnancy with prior history of postpartum eclampsia. BMJ Case Rep. 2020 Nov 3;13(11):e235582. doi: 10.1136/bcr-2020-235582. PMID: 33148572; PMCID: PMC7640453.
Béquet YLBN, van der Hoorn MLP, Lashley EELO. Highlighting inaccurate data supporting prednisolone administration in recurrent pregnancy loss: Comments on frequently cited meta-analysis. Am J Reprod Immunol. 2024 Feb;91(2):e13815. doi: 10.1111/aji.13815. PMID: 38414234.
Youssef A, Lashley L, Dieben S, Verburg H, van der Hoorn ML. Defining recurrent pregnancy loss: associated factors and prognosis in couples with two versus three or more pregnancy losses. Reprod Biomed Online. 2020 Oct;41(4):679-685. doi: 10.1016/j.rbmo.2020.05.016. Epub 2020 Jun 5. PMID: 32811769.
Lashley LE, van der Hoorn ML, Scherjon SA. Pre-eclampsie als complicatie bij eiceldonatie: een ander pathofysiologisch mechanisme? [Pre-eclampsia as a complication of egg donation: a different pathophysiological mechanism?]. Ned Tijdschr Geneeskd. 2010;154:A1982. Dutch. PMID: 20977786.